Statins you can However, there are 2 other drugs that must be taken at bedtime or just after dinner. As per observations, statins are best taken at night, as they have half-lives of even less than six hours. With these two drugs, they only have high blood concentrations for a period of less than 6 The half life of Lipitor is 14 hours and its active metabolites up to 20 to 30 hours therefore Lipitor can be taken at anytime. First of all, don't drink grapefruit juice or eat grapefruit at the same time you are taking the statin. Lovastatin should be taken with dinner. Statins are the most commonly prescribed medications for lowering high cholesterol levels. Princeton Longevity Center Princeton New Jersey 104 Carnegie Center Drive Princeton , NJ 08540 (888) 800-0752 6 comments on “ Class Act: Do Statins Always Have to Be Taken in the Evening? A 1996 study in the “Journal of Clinical Pharmacology” suggested that atorvastatin seemed to be just as effective whether it was taken in the morning or evening 4 . If a statin has a half life of less than 6 hours it should be taken at night. Many studies have shown that they work best if they are taken in the late evening or night. They are simvastatin (Zocor) or lovastatin (Mevacor). However, some statins, such as atorvastatin, are eliminated from your body more slowly than others, so their therapeutic effect lasts longer. Statins are often taken indefinitely; they are long-term maintenance drugs. Read more to find out which Statins you should take at bedtime and which are okay for the morning. Lipitor can be taken at anytime. A couple of things to remember about this type of drug. But why exactly should you take statins at night? If you miss a dose of the medication, be sure to consult your doctor about what to … For some types of statin it does not matter what time of day you take it, as long as you stick to the same time. Let's take a look. However, the extended-release version of lovastatin, Altoprev, should be taken at bedtime. Fluvastatin has a half-life of about three hours, so it should also be taken at night. Some types of statin should be taken in the evening. kalai on January 11th, 2008 - 7:38am Atorvastatin also has an active metabolite which has a … Statins come as tablets that are taken once a day. Some statins can be taken at any time of the day - ask your pharmacist to find out when you should be taking your medication.